Superficial acral fibromyxoma on the tip of the big toe: expression of CD10 and nestin

Editor Superficial acral fibromyxoma is a rare, distinctive soft tissue benign neoplasm that has a predilection to develop on the hands and feet of adults. Except for the only rare location on the palm, superficial acral fibromyxoma usually involves the fingers and toes, and the big toe tends to be the most frequently affected site. Most cases of superficial acral fibromyxoma tend to occur in either the subungal or periungal regions, although only two rare cases occurring on the ventral surface of the digit have been previously described. We herein report a case of superficial acral fibromyxoma, which developed at the most common site (i.e. the big toe), but it occurred in a rare region of this toe (i.e. on the tip of the toe). A 53-year-old healthy man presented with an asymptomatic, slowly growing nodule with a 3-year history on the tip of his right big toe. Examinations revealed a hemisphere-shaped, slightly reddish nodule, measuring 1.0 cm × 0.8 cm × 0.7 cm in size, on the tip of his right big toe (fig. 1a). Neither the involvement of the ungal region by the lesion nor any deformity of the nail plate was seen. Computed tomography scanning as well as plane radiographs revealed no involvement of the bone and no bone alterations. The nodule was completely excised, and a V-Y local advancement flap was also applied to the defect. Neither recurrence nor metastasis has been observed in the subsequent 1-year follow-up. Histopathologically, the excised nodule was a wellcircumscribed, globularly projecting lesion, which was located in the whole dermis while pushing against the subcutis (fig. 1b). The lesion was composed of proliferated spindle and stellate cells with random, loose storiform, and fascicular patterns, which were embedded in myxoid or myxocollagenous stroma (fig. 2a,b). The proliferating cells showed no nuclear atypia, and strands of cells with wavy nuclei were sometimes seen. The accentuated vasculature and some inflammatory cells, composed of mast cells and lymphocytes, were also involved within the lesion. Alcian blue staining revealed abundant mucinous material within the stroma. Immunohistochemical study revealed that most of the neoplastic cells (> 80%) were positive for CD34, CD99, CD10, and Vimentin (fig. 2c), and they were negative for S-100 protein, epithelial membrane antigen. Factor XIIIa labelled only scattered dendritic cells within the lesion. Nestin was positive for about 30% of the neoplastic cells, mainly in myxoid area (fig. 2d). The histopathological and immunohistochemical features in the presented case closely corresponded to those of superficial acral fibromyxoma. From a clinical point of view, the important points in superficial acral fibromyxoma are as follows: (i) a frequent deformity of the nail plate, (ii) a usual need for the removal of the nail plate during surgical procedures, and (iii) a rare deformity of the bone, because most cases of this condition affect either the subungal or periungal